User talk:ElNando888/Blog/Outsider

Double T Stacking Example

Nando, I find this extremely interesting.  What is the PDB entry and positions?

I've been thinking about how T stacking, in combination with more common stacking, might create enough energetic non-linearity in the poly(A) molecule to account for the fact that any particular lab sequence seems to form into a well-defined structure (i.e. not enough variation among the thousands of instances of that sequence to turn all the SHAPE values into "average" values), and yet the formations look so different for molecules with only slightly different sequences at the 3' end of the poly(A).