User:ElNando888/Blog/Mimic
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< User:ElNando888 | Blog
This entry won't develop much to a blog post. I'm just throwing ideas in the context of a discussion I'm having with Brourd about mimcs.
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| FMN | Sarcin-ricin (15 nts) |
The top half is structurally quite similar, but the bottom differs a bit. Specifically, it is undeniable that the FMN molecule offers a much larger stacking area than the A+A platform in motif IL_85647.3
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_stacking_pattern.png) |
| FMN | Sarcin-ricin (13 nts) |
A possible way to compensate the difference would be to use a reduced form of the loop, with an additional cWW pair, like in motif IL_49493.4
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By the way, this canonical pairs mimic...
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I'm counting -11.9 kcal, much more than the -4.9 that we're supposed to mimic...
