Ribosome: Difference between revisions

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<p>The <strong>ribosome</strong> is the nanomachine that translates RNA [[base]]s from [[messenger RNA]] into [[amino acid]]s and [[protein]]s. The principle function of a ribosome is to take [[messenger RNA]] (mRNA) derived from genes (typically stored as DNA) and use them as a template or recipe to construct poly-peptides ([[protein]]s) by matching 3-base RNA triplets (codons), one at a time, to [[amino acid]]s using transfer rna (tRNA) to aid in the process.</p>
<p>[[File:Ribosome_shape.png|thumb|300px|<span>Structure and shape of the </span><em>[[E. coli]]</em><span>&nbsp;70S ribosome. The large 50S ribosomal subunit (red) and small 30S ribosomal subunit (blue) are shown with a 200 &Aring;ngstrom (20 nm) scale bar. For the 50S subunit, the 23S (dark red) and 5S (orange red) [[rRNA]]s and the ribosomal proteins (pink) are shown. For the 30S subunit, the 16S rRNA (dark blue) and the ribosomal proteins (light blue) are shown.</span>]]The <strong>ribosome</strong> is the nanomachine that translates RNA [[base]]s from [[messenger RNA]] into [[amino acid]]s and [[protein]]s. The principle function of a ribosome is to take [[messenger RNA]] (mRNA) derived from genes (typically stored as DNA) and use them as a template or recipe to construct poly-peptides ([[protein]]s) by matching 3-base RNA triplets ([[codon]]s), one at a time, to [[amino acid]]s using [[transfer RNA]] (tRNA) to aid in the process.</p>
<h2>Teaching about Ribosomes</h2>
 
== Teaching about Ribosomes ==
<ul>
<ul>
<li>[http://theoncologist.alphamedpress.org/content/5/6/508.full The Molecular Perspective: The Ribosome]</li>
<li>[https://theoncologist.onlinelibrary.wiley.com/doi/full/10.1634/theoncologist.5-6-508 The Molecular Perspective: The Ribosome]</li>
<li>[http://blogs.sciencemag.org/origins/2009/02/deconstructing-the-ribosome.html Deconstructing the Ribosome] </li>
<li>[http://blogs.sciencemag.org/origins/2009/02/deconstructing-the-ribosome.html Deconstructing the Ribosome] </li>
<li>[http://en.wikipedia.org/wiki/Ribosome Ribosome - Wikipedia]</li>
<li>[http://en.wikipedia.org/wiki/Ribosome Ribosome - Wikipedia]</li>
</ul>
</ul>
<h2>Labs and Puzzles for Ribosomes</h2>
 
== Labs and Puzzles for Ribosomes ==
<ul>
<ul>
<li>[https://eternagame.org/web/lab/9215705/ Ribosome Pilot Challenge Warm-Up Lab]</li>
<li>[https://eternagame.org/web/lab/9215705/ Ribosome Pilot Challenge Warm-Up Lab]</li>
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<li>[https://eternagame.org/web/playerpuzzles/?search=Ribosome&amp;sort=date Ribosome Player-Puzzles]</li>
<li>[https://eternagame.org/web/playerpuzzles/?search=Ribosome&amp;sort=date Ribosome Player-Puzzles]</li>
</ul>
</ul>
<h2>Selected Forum Posts</h2>
 
== Selected Forum Posts ==
<ul>
<ul>
<li>[https://getsatisfaction.com/eternagame/topics/ribosome-pilot-challenge Ribosome Pilot Challenge]</li>
<li>[https://forum.eternagame.org/t/redesigning-the-ribosome-chemical-goals/3068 Redesigning the ribosome: chemical goals]</li>
<li>[https://getsatisfaction.com/eternagame/topics/redesigning-the-ribosome-chemical-goals Redesigning the ribosome: chemical goals]</li>
<li>[https://forum.eternagame.org/t/ribosome-challenge-puzzles-of-the-week/3074 Ribosome Challenge Puzzles of the Week]</li>
<li>[https://getsatisfaction.com/eternagame/topics/ribosome-challenge-puzzles-of-the-week Ribosome Challenge Puzzles of the Week]</li>
<li>[https://forum.eternagame.org/t/domain-structure-of-the-ribosome/3072 Domain structure of the Ribosome]</li>
<li>[https://getsatisfaction.com/eternagame/topics/domain-structure-of-the-ribosome Domain structure of the Ribosome]</li>
<li>[https://forum.eternagame.org/t/ribosome-pilot-challenge/3090&nbsp;Ribosome Pilot Challenge]</li>
</ul>
</ul>
<h2>Puzzle Solving Resources</h2>
 
== Puzzle Solving Resources ==
<ul>
<ul>
<li>[https://eternagame.org/web/player/259016/ prestonzen] is creating another great resource for learning to solve Eterna puzzles -- YouTube video walk-throughs. His first&nbsp;Ribosome Challenge video, where he solves puzzle 1.7, is a very gentle introduction.</li>
<li>[https://eternagame.org/web/player/259016/ prestonzen] is creating another great resource for learning to solve Eterna puzzles -- YouTube video walk-throughs. His first&nbsp;Ribosome Challenge video, where he solves puzzle 1.7, is a very gentle introduction.</li>
<li>[https://eternagame.org/web/player/215715/ Astromon]'s&nbsp;<a href="https://docs.google.com/presentation/d/1tryel6znJc7DF7mjojRwzVaJeK8Rm5w9s9aRFMsNeZY/edit#slide=id.g5a6ab68da6_0_0">Guide for the Ribosome labs/challenges and The Soft Constraint booster</a>.</li>
<li>[https://eternagame.org/web/player/215715/ Astromon]'s&nbsp;[https://docs.google.com/presentation/d/1tryel6znJc7DF7mjojRwzVaJeK8Rm5w9s9aRFMsNeZY/edit#slide=id.g5a6ab68da6_0_0 Guide for the Ribosome labs/challenges and The Soft Constraint booster].</li>
<li>[https://eternagame.org/web/player/8627/ Eli]'s&nbsp;<a href="https://docs.google.com/document/d/1UHLuJm8Xh0td_lzWHMv-tp_7fCRCK630LBseGC7-nZY/edit#heading=h.rrdxtye6vn90">Solving ribosome challenge puzzles</a>&nbsp;document.</li>
<li>[https://eternagame.org/web/player/8627/ Eli]'s&nbsp;[https://docs.google.com/document/d/1UHLuJm8Xh0td_lzWHMv-tp_7fCRCK630LBseGC7-nZY/edit#heading=h.rrdxtye6vn90 Solving ribosome challenge puzzles]&nbsp;document.</li>
<li>The&nbsp;<a href="https://docs.google.com/presentation/d/1Q9qVUBm3l5k4lZ3hhnoObWsQhvELrfQEfslZOnWTFOs/edit#slide=id.g5d1d569447_0_0">slide presentation</a>&nbsp;from [https://eternagame.org/web/player/57675/ Omei]'s Eternacon presentation.</li>
</ul>
</ul>
<h2>Puzzle Construction/Analysis Resources</h2>
 
== Puzzle Construction/Analysis Resources ==
<ul>
<ul>
<li>[https://docs.google.com/document/d/1WHhQAYo1lPzII5It0gRLQKxUkY9fwmvRpVe4ouCV98g/edit&nbsp;Ribosome Challenge Puzzle Creation] contans the scondary structure, starting sequence, IUPAC constraints and locks for the three major robosome units and their domains.</li>
<li>[https://docs.google.com/document/d/1WHhQAYo1lPzII5It0gRLQKxUkY9fwmvRpVe4ouCV98g/edit?usp=sharing Ribosome Challenge Puzzle Creation] contains the scondary structure, starting sequence, IUPAC constraints and locks for the three major robosome units and their domains.</li>
<li>[http://apollo.chemistry.gatech.edu/RibosomeGallery/bacteria/index.html Secondary structure diagrams] for ''E. coli'' and related bacteria</li>
</ul>
</ul>
<p>&nbsp;</p>
<p>[[Category:Proteins]][[Category:RNA]][[Category:Scientific Terminology]]</p>
<ul>
<ul>
</ul>
</ul>

Latest revision as of 08:17, 18 June 2022

Structure and shape of the E. coli 70S ribosome. The large 50S ribosomal subunit (red) and small 30S ribosomal subunit (blue) are shown with a 200 Ångstrom (20 nm) scale bar. For the 50S subunit, the 23S (dark red) and 5S (orange red) rRNAs and the ribosomal proteins (pink) are shown. For the 30S subunit, the 16S rRNA (dark blue) and the ribosomal proteins (light blue) are shown.

The ribosome is the nanomachine that translates RNA bases from messenger RNA into amino acids and proteins. The principle function of a ribosome is to take messenger RNA (mRNA) derived from genes (typically stored as DNA) and use them as a template or recipe to construct poly-peptides (proteins) by matching 3-base RNA triplets (codons), one at a time, to amino acids using transfer RNA (tRNA) to aid in the process.

Teaching about Ribosomes

Labs and Puzzles for Ribosomes

Selected Forum Posts

Puzzle Solving Resources

Puzzle Construction/Analysis Resources

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