Aptamer: Difference between revisions

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<p>An aptamer is an nucleic acid that binds a target molecule.</p>
<p>An aptamer is a [[What is RNA|nucleic acid]] that binds a target molecule.</p>
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<h2>Comparison to Antibodies</h2>
<h2>Comparison to Antibodies</h2>
<div>[[File:Aptamer_1FMN.jpg|thumb]]Like antibodies, RNA aptamers can be extremely specific to a target and are capable of discriminating between closely related molecules. RNA aptamers and antibodies can be generated to bind a similarly diverse array of targets. Antibodies, however, are composed of protein and must be produced by the immune cells of a living organism. Novel aptamers can be selected quicky in vitro and amplified by PCR.</div>
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<p>Like antibodies, RNA aptamers can be extremely specific to a target and are capable of discriminating between closely related molecules. RNA aptamers and antibodies can be generated to bind a similarly diverse array of targets. Antibodies, however, are composed of protein and must be produced by the immune cells of a living organism. Novel aptamers can be selected quicky in vitro and amplified by PCR.</p>
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<td>[[File:Aptamer_1FMN.jpg|thumb|300px]]</td>
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<h2>Selection of Aptamers</h2>
<h2>Selection of Aptamers</h2>
<p>[[File:SelexWEB.jpg|thumb]]RNA aptamers are generated by selection. The selection process begins with a large library of random sequences and removes RNAs that do not bind the target or bind nonspecifically. The selected RNAs are isolated, reverse-transcribed, amplified, and the process is repeated.</p>
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<td>RNA aptamers are generated by selection. The selection process begins with a large library of random sequences and removes RNAs that do not bind the target or bind nonspecifically. The selected RNAs are isolated, reverse-transcribed, amplified, and the process is repeated.</td>
<td>[[File:SelexWEB.jpg|thumb|300px]]</td>
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<h2>Teaching about Aptamers</h2>
<p>[http://eternawiki.org/wiki/index.php5/User:ElNando888/Blog/Aptamers Aptamers and bonuses]&nbsp;by&nbsp;[[User:ElNando888|Nando]]</p>
<p>[http://eterna.cmu.edu/web/blog/?skip=5&amp;size=5&nbsp;<span>Riboswitches and science on coffee] by&nbsp;<span>[[User:Eli Fisker|Eli Fisker]]</span></span></p>
<p><span><span>[http://www.scienceinafrica.com/biotechnology/industrial/nuts-and-bolts-genius-behind-aptamers-future-drug-delivery The nuts and bolts of the genius behind aptamers - the future for drug delivery]</span></span></p>

Revision as of 12:02, 30 January 2015

An aptamer is a nucleic acid that binds a target molecule.

 

Comparison to Antibodies

<tbody> </tbody>

Like antibodies, RNA aptamers can be extremely specific to a target and are capable of discriminating between closely related molecules. RNA aptamers and antibodies can be generated to bind a similarly diverse array of targets. Antibodies, however, are composed of protein and must be produced by the immune cells of a living organism. Novel aptamers can be selected quicky in vitro and amplified by PCR.

Aptamer 1FMN.jpg

 

Selection of Aptamers

<tbody> </tbody>
RNA aptamers are generated by selection. The selection process begins with a large library of random sequences and removes RNAs that do not bind the target or bind nonspecifically. The selected RNAs are isolated, reverse-transcribed, amplified, and the process is repeated.
SelexWEB.jpg

Teaching about Aptamers

Aptamers and bonuses by Nando

Riboswitches and science on coffee by Eli Fisker

The nuts and bolts of the genius behind aptamers - the future for drug delivery